Constantin T Yiannoutsos, Ph.D. Professor Indiana University School of Medicine 410 West 10th Street, Suite 3000 Indianapolis, IN 46202 email: cyiannou@iupui.edu Tel.: (317) 278-3045 Fax: (317) 274-2678
Education
Ph.D. Statistics (1991), University of Connecticut, Storrs, CT.
M.S. Statistics (1987), University of Connecticut, Storrs, CT.
Research
Methodological interests
Application-motivated research in diagnostic test validation, sequential models, clinical-trial design and Bayesian methods.
Main areas of collaboration
HIV/AIDS
· Read a presentation about data-driven search for changes in risk after initiation of antiretroviral therapy in Africa based on piece-wise Weibull models. Both the one and two-parameter maximization were performed with the STATA ML procedures. Also, read LJ Jiwanis MSc thesis from Simon Fraser University on piece-wise Weibull models and Germn Rodriguezs treatment of the piece-wise exponential model.
· Read detailed analyses of weight changes after ARV initiation in Kenya (from Wools-Kaloustian et al., AIDS, 2006).
Oncology
· Read an analysis about PSA doubling time and change point mixed models of PSA growth.
· Read an presentation of various estimates of the LD50 in animal experiments.
Publications
Here is a list of selected publications. For a comprehensive list of publications click here.
1. Hall CD, Dafni U, Simpson D, Clifford D, Wetherill P, Cohen B, McArthur JC, Hollander H, Yiannoutsos CT,Major E,Millar L, Timpone J: Failure of Cytosine Arabinoside Therapy of Human Immunodeficiency Virus-I Associated Progressive Multifocal Leucoencephalopathy. New England Journal of Medicine, 1998; 338:19, 1345-51. Get the NEJM citation. See also comment by J.E. Greenlee.
2. Chen, MH, Ibrahim, JG, and Yiannoutsos, C. Prior Elicitation, Variable Selection and Bayesian Computation for Logistic Regression Models, Journal of the Royal Statistical Society, Series B, 1999; 61(1) 223-242. Get the article.
3. Yiannoutsos CT, Major EO, Curfman B, Jensen PN, Gravell M, Hou J, Clifford DB, Hall CD. Relation of JC virus DNA in the CSF to survival in AIDS patients with biopsy-proven Progressive Multifocal Leukoencephalopathy. Annals of Neurology, 1999; 45(6) 816-820.
4. Price RW, Yiannoutsos CT, Clifford DB, Zaborski L, Tselis A, Sidtis JJ, Cohen B, Hall CD, Erice A, and Henry K. Neurological outcomes in late-stage HIV-1 infection: adverse influence of neurological impairment on Survival and protective effect of antiviral therapy. AIDS, 1999; 13: 1677-1686. Get the article.
5. Simpson DM, Haidich AB, Schifitto G, Yiannoutsos CT, Geraci AP, McArthur JC, Katzenstein DA. Severity of HIV-associated Neuropathy is Associated with Plasma HIV-1 RNA Levels. AIDS, 2002; 16(3): 407-412. Get the article.
6. Polydefkis M, Yiannoutsos CT, Shriver S, Simpson DM, Cohen BA, Adornato BT, Hollander H, Marra CM, Clifford DB and McArthur JC. Intraepidermal nerve fiber density in HIV-associated sensory neuropathy. Neurology, 2002; 58(1): 115-119. Get the article.
7. Lee PL, Yiannoutsos CT, Ernst T, Chang L, Marra CM, Jarvik JG, Richards TL, Kwok EW, Kolson DL, Simpson D, Tang CY, Schifitto G, Ketonen LM, Meyerhoff DJ, Lenkinski RE, Gonzalez RG, Navia BA. MRS study of the AIDS dementia complex: Validation and preliminary analysis. J Magn Reson Imaging. 2003; 17(6):625-33. Get the article.
8. Nakas C, Yiannoutsos CT, Bosch RJ, Moyssiadis C. Assessment of diagnostic markers by goodness-of-fit tests. Statist Med; 2003; 22(15): 2503-2513. Get the article.
9. Nakas CT, Yiannoutsos CT. Ordered multiple class ROC analysis with continuous measurements. Statist Med 2004; 23: 3437-3449. Get the article.
10. Yiannoutsos CT, Ernst T, Chang L, Lee PL, Richards T, Marra C, Meyerhoff DJ, Jarvic J, Kolson D, Schifitto G, Ellis RJ, Swindells, Simpson DM, Miller EN, Gonzalez RG, Navia BA. Patterns of regional brain metabolism and diagnostic utility of proton MRS in AIDS Dementia Complex. Neuroimage 2004; 23(3): 928:935. Get the article.
11. Li L, Shi H, Yiannoutsos CT, Huang T-H-M, Nephew KP. Epigenetic hypothesis tests for methylation and acetylation in a triple microarray system. J Comp Biol, 2005; 12(3):270-390. Get the article.
12. Sweeney C, Liu G, Yiannoutsos CT, Kolesar J, Horvath D, Staab MJ, Fife K, Armstrong V, Treston A, Sidor C, Wilding G. A Phase II multicenter, randomized, double-blind, safety, PK, PD, and efficacy study of oral 2-methoxyestradiol in hormone refractory prostate cancer. Clin Cancer Res, 2005; 11(18): 6625-6633. Get the article. See more details of the changepoint model.
13. Wools-Kaloustian K, Kimaiyo S, Diero L, Siika AM, Sidle J, Yiannoutsos CT, Musick BS, Einterz RM, Fife KH, Tierney, WM The clinical and immunologic outcomes of an antiretroviral treatment program in western Kenya: retrospective cohort study. AIDS, 2006; 20:41-48. Get the article. Read detailed analyses of weight changes after ARV initiation in Kenya.
14. Wruck LM, Yiannoutsos CT, Hughes, MD. A sequential design to estimate sensitivity and specificity of a diagnostic test. Stat Med, 2006; 25:3458-3473. Get the article.
Teaching
I have taught a number of courses at a number of institutions both in the US and around the world. In addition to the Division of Biostatistics at Indiana University, these include Harvard University Extension School, in Cambridge, MA, the University of Athens Medical School in Athens, Greece, and, more recently, the Moi University School of Public, in Eldoret, Kenya.
Here are notes from classes I have taught in the past.
· Introduction to Biostatistics I (taught with STATA)
o Lectures (book format)
o Labs
· Introduction to Biostatistics II (taught with SAS)
· Introduction to Biostatistics II (taught with SPSS; includes video)
· Generalized Linear Models (taught with STATA) also see the excellent presentation by Germn Rodriguez at Princeton from where many of the ideas for these notes were taken.
· Applied Survival Analysis (taught with STATA)
o Labs (stata)
o Labs (SAS)
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